Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30398306 | 0.84 | GRM2 (0.38) | GRM2MAPK13 | |
| SCHEMBL30396233 | 0.84 | GRM2 (0.38) | GRM2MAPK13 | |
| SCHEMBL30397338 | 0.79 | SMN1; SMN2 (0.43) | GRM2KMT2AALDH1A1MEN1 | |
| SCHEMBL30397943 | 0.77 | MAPK13 (0.41) | GRM2MAPK13ADORA2A | |
| SCHEMBL30397669 | 0.77 | MAPK13 (0.41) | GRM2MAPK13ADORA2A | |
| SCHEMBL25526353 | 0.77 | GRM2 (0.43) | GRM2MAPK13 | |
| SCHEMBL25523929 | 0.76 | GRM2 (0.40) | GRM2MAPK13ALDH1A1ADORA2A | |
| SCHEMBL25521381 | 0.74 | GRM2 (0.40) | GRM2MAPK13DRD2DRD3 | |
| SCHEMBL25522679 | 0.74 | GRM2 (0.40) | GRM2MAPK13 | |
| SCHEMBL30397938 | 0.73 | MAPK13 (0.42) | GRM2MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |