Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578835 | 0.83 | CTBP2 (0.55) | MTNR1AMTNR1BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7387748 | 0.82 | HTT (0.56) | MTNR1AMTNR1BGAAALDH1A1CYP3A4 | |
| SCHEMBL348963 | 0.81 | HSP90AB1 (0.62) | KDM4EGAAHSP90AB1ALDH1A1CYP3A4 | |
| Nitrogen SCHEMBL28021203 | 0.79 | HTT (0.53) | MTNR1AMTNR1BGAAALDH1A1CYP3A4 | |
| SCHEMBL1162659 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1CYP3A4MAPK8SMN1; SMN2 | |
| SCHEMBL13543196 | 0.78 | CYP24A1 (0.50) | KDM4EGAAALDH1A1MAPK8L3MBTL1 | |
| SCHEMBL1295492 | 0.77 | KDM4E (0.43) | KDM4EGAAALDH1A1MAPK8SMN1; SMN2 | |
| SCHEMBL1872932 | 0.76 | SMN1; SMN2 (0.55) | GAAHSP90AB1ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL19974287 | 0.76 | MTNR1A (0.42) | MTNR1AMTNR1BGAAHSP90AB1L3MBTL1 | |
| SCHEMBL25972162 | 0.76 | MTNR1A (0.47) | MTNR1AMTNR1BHSP90AB1MAPK8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |