SCHEMBL25527361

SCHEMBL25527361

O=C(CS)Oc1c(C(=O)O)cc(F)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
MAPT P10636 1/20 0.33
KDM4E B2RXH2 1/20 0.31
ASPH Q12797 1/20 0.31
KDM8 Q8N371 1/20 0.31
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
DCLRE1B Q9H816 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182462 0.78 KDM4E (0.45) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL28603127 0.75 KEAP1 (0.48) KEAP1NFE2L2MAPTKDM4EASPH
SCHEMBL25527351 0.75 LMNA (0.39) MAPTKDM4ECES2CES1
SCHEMBL1408238 0.74 TSHR (0.44) MAPT
SCHEMBL25527367 0.74 ALB (0.47) MAPTKDM4ECES2CES1DCLRE1B
SCHEMBL1617264 0.74 HSD17B10 (0.49) KEAP1NFE2L2MAPTKDM4E
SCHEMBL25527356 0.73 POLB (0.32) MAPT
SCHEMBL25527385 0.71 MAOB (0.39)
Fluoride SCHEMBL28471027 0.68 KEAP1 (0.47) KEAP1NFE2L2KDM4EASPHKDM8
Fluoride SCHEMBL6445071 0.68 KEAP1 (0.47) KEAP1NFE2L2KDM4EASPHKDM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230152696-A1 POSITIVE RESIST COMPOSITION AND PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-05-18 US disclosed