Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 3/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488433 | 1.00 | HTR1A (0.45) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL488775 | 1.00 | HTR1A (0.45) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL16716869 | 1.00 | HTR1A (0.45) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL5219148 | 0.98 | CHRM5 (0.46) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| Hydrochloric Acid SCHEMBL18424980 | 0.98 | HTR1A (0.44) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL10326492 | 0.98 | CHRM5 (0.46) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL10326687 | 0.98 | CHRM5 (0.46) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL13620120 | 0.98 | CHRM5 (0.46) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL1995891 | 0.98 | CHRM5 (0.46) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL2387767 | 0.98 | CHRM5 (0.46) | HTR1AHTR2AKCNH2HTR1DHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 689 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2957575-B1 | OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT | NAT UNIV CORP KANAZAWA UNIV (JP) | 2017-10-18 | — | — | EP | claimed |
| US-9562121-B2 | Optically active poly(diphenylacetylene) compound, preparation method therefor, and use thereof as optical isomer separating agent | NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) | 2017-02-07 | — | — | US | claimed |
| CN-103232491-B | A kind of preparation method of cyclic phosphoric acid | 河北科技大学 | 2016-06-15 | — | — | CN | claimed |
| US-9290592-B2 | Poly(diphenylacetylene) compound, preparation method therefor, and use thereof as optical isomer separating agent | NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) | 2016-03-22 | — | — | US | claimed |
| US-20150376308-A1 | OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT | NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) | 2015-12-31 | — | — | US | claimed |
| US-20150376309-A1 | NEW POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT | National University Corporation Kanazawa University of Ishikawa ,Japan | 2015-12-31 | — | — | US | claimed |
| EP-2957575-A1 | OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT | National University Corporation Kanazawa University (JP) | 2015-12-23 | — | — | EP | claimed |
| EP-1831206-B1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY | OSI PHARM INC (US) | 2011-08-24 | — | — | EP | claimed |
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | claimed |
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | ELAN PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | claimed |
| US-20060281733-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. | 2006-12-14 | — | — | US | claimed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | claimed |
| WO-2006060381-A2 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY | OSI PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | WO | claimed |
| US-20060116402-A1 | N-substituted benzimidazolyl c-Kit inhibitors and combinatorial benzimidazole library | OSI PHARMACEUTICALS, INC. | 2006-06-01 | — | — | US | claimed |
| US-20050020659-A1 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. | 2005-01-27 | — | — | US | claimed |
| EP-0873298-A4 | CHIRAL REDUCTIONS OF IMINES LEADING TO THE SYNTHESES OF OPTICALLY ACTIVE AMINES | NPS PHARMA INC (US) | 2000-05-17 | — | — | EP | claimed |
| EP-0873298-A1 | CHIRAL REDUCTIONS OF IMINES LEADING TO THE SYNTHESES OF OPTICALLY ACTIVE AMINES | NPS PHARMACEUTICALS, INC. (US) | 1998-10-28 | — | — | EP | claimed |
| US-5648541-A | FORMING ENANTIOMERS FROM IMINES BY REDUCTION WITH LITHIUM ALUMINUM HYDRIDE | NPS PHARMACEUTICALS, INC. (US) | 1997-07-15 | — | — | US | claimed |
| WO-1997011934-A1 | CHIRAL REDUCTIONS OF IMINES LEADING TO THE SYNTHESES OF OPTICALLY ACTIVE AMINES | NPS PHARMACEUTICALS, INC. (US) | 1997-04-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020659-A1 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | BDKRB1, BDKRB2, BRS3 | HTR1A 318/4885HTR2A 900/4885KCNH2 225/4885 |
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | BDKRB1, BDKRB2, NPBWR1 | HTR1A 345/4885HTR2A 742/4885KCNH2 377/4885 |
| US-20060281733-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | BDKRB1, BDKRB2, CNR1 | HTR1A 837/4885HTR2A 1442/4885KCNH2 550/4885 |
| US-20060116402-A1 | N-substituted benzimidazolyl c-Kit inhibitors and combinatorial benzimidazole library | KIT, CHUK, TNNI3K | HTR1A 4095/4885HTR2A 4506/4885KCNH2 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.