Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25529454 | 0.86 | BTK (0.40) | METKMT2AL3MBTL1BTKBRD4 | |
| SCHEMBL25524581 | 0.82 | MET (0.43) | METKMT2AL3MBTL1BTKKIT | |
| SCHEMBL30397273 | 0.81 | BTK (0.42) | METKMT2AL3MBTL1BTKMAPK13 | |
| SCHEMBL25523570 | 0.81 | BTK (0.44) | METKMT2AL3MBTL1BTKMAPK13 | |
| SCHEMBL25540760 | 0.80 | MET (0.39) | METKMT2AL3MBTL1BTKKIT | |
| SCHEMBL25528178 | 0.79 | MET (0.39) | METKMT2AL3MBTL1BTKKIT | |
| SCHEMBL25523600 | 0.78 | KMT2A (0.41) | METKMT2AL3MBTL1BTKMAPK13 | |
| SCHEMBL25529486 | 0.78 | MAPK14 (0.42) | BRD4MAPK14MAPK13 | |
| SCHEMBL25517566 | 0.77 | KMT2A (0.49) | KMT2AL3MBTL1BTKKITMAPK13 | |
| SCHEMBL30397426 | 0.77 | USP30 (0.41) | METKMT2AL3MBTL1BTKCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |