Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397398 | 0.87 | MAPK13 (0.43) | KMT2AL3MBTL1BTKALDH1A1GAA | |
| SCHEMBL25523570 | 0.83 | BTK (0.44) | KMT2AL3MBTL1BTKALDH1A1GAA | |
| SCHEMBL30397273 | 0.82 | BTK (0.42) | KMT2AL3MBTL1BTKMAPK13MET | |
| SCHEMBL25523622 | 0.80 | ALDH1A1 (0.40) | KMT2AL3MBTL1ALDH1A1NPSR1MAPT | |
| SCHEMBL25517566 | 0.80 | KMT2A (0.49) | KMT2AL3MBTL1BTKALDH1A1MAPT | |
| SCHEMBL25529454 | 0.79 | BTK (0.40) | KMT2AL3MBTL1BTKMAPK13MET | |
| SCHEMBL25524768 | 0.78 | MAPK13 (0.44) | KMT2AL3MBTL1BTKMAPK13JAK2 | |
| SCHEMBL25540956 | 0.78 | BTK (0.42) | KMT2AL3MBTL1BTKMAPK13MET | |
| SCHEMBL25529477 | 0.78 | MET (0.39) | KMT2AL3MBTL1BTKMAPK13MET | |
| SCHEMBL25524384 | 0.78 | KMT2A (0.42) | KMT2AL3MBTL1BTKMAPTMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |