Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CD74 | P04233 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25529498 | 0.89 | MAPT (0.48) | MAPTMAPK8TRPA1CYP4F2CYP4A11 | |
| SCHEMBL25530633 | 0.82 | ROCK2 (0.45) | MAPTTRPA1CYP4F2CYP4A11L3MBTL1 | |
| SCHEMBL25529500 | 0.74 | ROCK2 (0.59) | MAPTTRPA1L3MBTL1MAPK10POLB | |
| SCHEMBL25530634 | 0.72 | ROCK2 (0.40) | ROCK2ROCK1IDO1 | |
| SCHEMBL25530880 | 0.71 | ROCK1 (0.48) | MAPTTRPA1L3MBTL1MAPK10POLB | |
| SCHEMBL28799626 | 0.71 | ALDH1A1 (0.62) | MAPTMAPK8TRPA1L3MBTL1IDO1 | |
| SCHEMBL15523614 | 0.67 | MAPT (0.53) | MAPTMAPK8CYP4F2CYP4A11MAPK10 | |
| SCHEMBL31753576 | 0.66 | KMT2A (0.70) | MAPTTRPA1CYP4F2CYP4A11L3MBTL1 | |
| SCHEMBL1164954 | 0.66 | KMT2A (0.70) | MAPTTRPA1CYP4F2CYP4A11L3MBTL1 | |
| SCHEMBL6179524 | 0.64 | MAPK8 (0.56) | MAPTMAPK8CYP4F2CYP4A11MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023093787-A1 | BENZODIAZEPINE COMPOUND AND APPLICATION THEREOF AS RHO KINASE INHIBITOR | 成都奥睿药业有限公司 | 2023-06-01 | — | — | WO | disclosed |