Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1625348 | 0.85 | LMNA (0.55) | TSHRMEN1KMT2ATDP1LMNA | |
| SCHEMBL3279844 | 0.85 | KMT2A (0.47) | TSHRMEN1KMT2ATDP1PTGS2 | |
| SCHEMBL19347482 | 0.84 | PTGS2 (0.38) | TSHRMEN1KMT2ATDP1PTGS2 | |
| Hydrochloric Acid SCHEMBL11037833 | 0.84 | LMNA (0.53) | TSHRMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL1792502 | 0.83 | ESR1 (0.53) | TSHRKMT2ATDP1LMNASMN1; SMN2 | |
| SCHEMBL9235662 | 0.83 | ESR1 (0.53) | TSHRKMT2ATDP1LMNASMN1; SMN2 | |
| SCHEMBL9232941 | 0.83 | ESR1 (0.53) | TSHRKMT2ATDP1LMNASMN1; SMN2 | |
| SCHEMBL28929197 | 0.83 | PTGS1 (0.43) | TSHRPTGS2LMNASMN1; SMN2MMP8 | |
| SCHEMBL13884372 | 0.82 | EPHX1 (0.45) | TSHRPTGS2EPHX1LMNA | |
| SCHEMBL12982066 | 0.82 | PTGS2 (0.40) | TSHRMEN1KMT2ATDP1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |