⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1654681 | 0.92 | ALDH1A1 (0.32) | — | |
| SCHEMBL7101333 | 0.90 | ALDH1A1 (0.36) | — | |
| SCHEMBL10854599 | 0.83 | — | — | |
| SCHEMBL4922033 | 0.76 | — | — | |
| SCHEMBL604854 | 0.76 | — | — | |
| SCHEMBL9934571 | 0.76 | — | — | |
| SCHEMBL10167903 | 0.75 | — | — | |
| SCHEMBL6830674 | 0.75 | RELA (0.33) | — | |
| SCHEMBL10807849 | 0.74 | — | — | |
| SCHEMBL11933655 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122208-A1 | CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF | RAPT THERAPEUTICS, INC. | 2025-04-17 | — | — | US | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| CN-110023292-B | Apoptosis inhibitors | 北京生命科学研究所 | 2022-10-04 | — | — | CN | disclosed |
| US-20210309647-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-10-07 | — | — | US | disclosed |
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| WO-2020154321-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| CN-110023292-A | Apoptosis inhibitor | 北京生命科学研究所 | 2019-07-16 | — | — | CN | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
| CN-1127492-C | Antirheumatic | SHIONOJI & CO LTD (JP) | 2003-11-12 | — | — | CN | disclosed |
| US-20030125364-A1 | Antirheumatic agent | MATSUMOTO SAICHI (JP) | 2003-07-03 | — | — | US | disclosed |
| US-6525081-B1 | Inhibiting osteoclast formation and nitrogen monoxide production; suppressing transcription factor NF kappa B | SHIONOGI & CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| CN-1283194-A | Antirheumatic | SHIONOJI & CO LTD (JP) | 2001-02-07 | — | — | CN | disclosed |
| EP-1026162-A1 | ANTIRHEUMATIC | SHIONOGI & CO., LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
| EP-0595546-B1 | Benzylidene derivatives | SHIONOGI & CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5418230-A | Antiinflammatory | SHIONOGI & CO., LTD. (JP) | 1995-05-23 | — | — | US | disclosed |
| EP-0595546-A1 | Benzylidene derivatives | SHIONOGI & CO., LTD. (JP) | 1994-05-04 | — | — | EP | disclosed |
| EP-0381132-A1 | Imidazopyridazines, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |
| EP-0211236-A1 | 7-Oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-02-25 | — | — | EP | disclosed |