Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25563495 | 0.82 | HDAC1 (0.44) | NR1H4SLC1A2AKR1C3AKR1C2HDAC1 | |
| SCHEMBL7932892 | 0.81 | NR1H4 (0.51) | NR1H4AKR1C3AKR1C2HDAC1LMNA | |
| SCHEMBL11516733 | 0.81 | NR1H4 (0.47) | NR1H4SLC1A2AKR1C3AKR1C2HDAC1 | |
| SCHEMBL25530546 | 0.79 | KIF11 (0.43) | NR1H4SLC1A2HDAC1LMNAALDH1A1 | |
| SCHEMBL8307755 | 0.76 | MAPT (0.44) | NR1H4SLC1A2HDAC1LMNAALDH1A1 | |
| SCHEMBL25541299 | 0.76 | KIF11 (0.45) | NR1H4SLC1A2HDAC1KIF11 | |
| SCHEMBL12937983 | 0.76 | LMNA (0.48) | LMNAALDH1A1CYP2D6HIF1A | |
| SCHEMBL27590403 | 0.76 | NR1H4 (0.54) | NR1H4AKR1C3AKR1C2HDAC1LMNA | |
| SCHEMBL12824192 | 0.76 | LMNA (0.48) | LMNAALDH1A1CYP2D6HIF1A | |
| SCHEMBL10140521 | 0.76 | LMNA (0.48) | LMNAALDH1A1CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | MPO, NISCH, RPN2 | NR1H4 3321/4885SLC1A2 4661/4885AKR1C3 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.