Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 7/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558496 | 0.91 | NPC1 (0.39) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL12340549 | 0.89 | GRM4 (0.42) | NPC1RAB9AAURKANTRK1HTT | |
| SCHEMBL12340581 | 0.88 | GRM4 (0.38) | NPC1RAB9AAURKANTRK1HTT | |
| SCHEMBL12340569 | 0.87 | PLAAT3 (0.45) | — | |
| SCHEMBL12340611 | 0.87 | GRM4 (0.37) | AURKANTRK1AURKBGRM4BRAF | |
| SCHEMBL2550733 | 0.86 | SMN1; SMN2 (0.43) | NPC1RAB9AAURKANTRK1HTT | |
| SCHEMBL12340671 | 0.83 | AURKA (0.44) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL12340497 | 0.83 | TP53 (0.35) | AURKANTRK1HTTMAP2K7BRAF | |
| SCHEMBL12340568 | 0.83 | AURKA (0.35) | AURKANTRK1HTTAURKBTP53 | |
| SCHEMBL12340523 | 0.81 | MGLL (0.43) | AURKANTRK1BACE1HTTCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040813-A1 | Fungicidal mixtures II comprising quinazolines | BASF SE (DE) | 2013-02-14 | — | — | US | claimed |
| US-20130035229-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-07 | — | — | US | claimed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| EP-2557926-A1 | FUNGICIDAL MIXTURES II COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-20 | — | — | EP | disclosed |
| EP-2557927-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-20 | — | — | EP | disclosed |
| US-20130040813-A1 | Fungicidal mixtures II comprising quinazolines | BASF SE (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20130035229-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-07 | — | — | US | disclosed |
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-8268843-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268843-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2012-09-18 | — | — | US | disclosed |
| WO-2011128843-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011128837-A1 | FUNGICIDAL MIXTURES II COMPRISING QUINAZOLINES | BASF SE (DE) | 2011-10-20 | — | — | WO | disclosed |
| WO-2010025451-A2 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | US | disclosed |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | NPC1 2297/4885CASP3 72/4885RAB9A 81/4885 |
| US-20130035229-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | CYP1A2, CYP3A7, CYP51A1 | NPC1 1021/4885CASP3 89/4885RAB9A 1130/4885 |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | NPC1 2297/4885CASP3 72/4885RAB9A 81/4885 |
| US-20130040813-A1 | Fungicidal mixtures II comprising quinazolines | CYP1A2, CYP3A7, CYP51A1 | NPC1 1215/4885CASP3 67/4885RAB9A 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.