Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 2/20 | 0.69 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 7/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392919 | 0.85 | YAP1 (0.83) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL25542768 | 0.82 | YAP1 (0.85) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL3312768 | 0.74 | KDM4E (0.70) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL3312796 | 0.73 | PKM (0.67) | YAP1TEAD4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21393070 | 0.73 | YAP1 (0.69) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL3319323 | 0.73 | KDM4E (0.71) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL23052172 | 0.71 | POLB (0.76) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL23052397 | 0.71 | POLB (0.76) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL25546052 | 0.71 | RNF114 (0.59) | YAP1TEAD4KDM4EMAPTRECQL | |
| SCHEMBL14133936 | 0.70 | KDM4E (0.76) | YAP1TEAD4KDM4EMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666661-B2 | Methods and compounds for targeted autophagy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666661-B2 | Methods and compounds for targeted autophagy | ATG7, BECN1, SQSTM1 | YAP1 1622/4885TEAD4 1748/4885KDM4E 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.