Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 7/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91155 | 0.79 | — | — | |
| Ammonia Solution, Strong SCHEMBL15467922 | 0.77 | — | — | |
| SCHEMBL27891094 | 0.77 | — | — | |
| SCHEMBL27968336 | 0.74 | DRD2 (0.44) | DRD2DRD3TAAR1ALDH1A1MEN1 | |
| SCHEMBL19497607 | 0.73 | CHKA (0.61) | ACHECHKABCHE | |
| SCHEMBL19504055 | 0.73 | CHKA (0.66) | ACHECHKABCHE | |
| Dimethylamine SCHEMBL7216210 | 0.73 | DRD2 (0.47) | DRD2DRD3TAAR1ALDH1A1RAB9A | |
| Bromide SCHEMBL19468820 | 0.72 | CHKA (0.64) | ACHECHKABCHE | |
| Bromide SCHEMBL19468768 | 0.72 | CHKA (0.69) | ACHECHKABCHE | |
| SCHEMBL5304667 | 0.71 | TP53 (0.64) | ACHECHKABCHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753371-B2 | Disulfiram derivatives as ALDH1A1 and MAGL inhibitors | BATTERJEE MEDICAL COLLEGE (SA) | 2023-09-12 | — | — | US | disclosed |
| US-20230174474-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | BATTERJEE MEDICAL COLLEGE (SA) | 2023-06-08 | — | — | US | disclosed |
| US-20230174475-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | BATTERJEE MEDICAL COLLEGE (SA) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753371-B2 | Disulfiram derivatives as ALDH1A1 and MAGL inhibitors | ALDH1A1, ADH1A, ALDH3A1 | ACHE 2616/4885DRD2 726/4885DRD3 771/4885 |
| US-20230174475-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | ADH1A, ALDH1A1, ALDH3A1 | ACHE 2341/4885DRD2 663/4885DRD3 970/4885 |
| US-20230174474-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | ALDH1A1, ADH1A, ALDH3A1 | ACHE 2616/4885DRD2 726/4885DRD3 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.