Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551915 | 1.00 | TSHR (0.41) | TSHRGLAPARP1PTGDR2NOTUM | |
| Hydrochloric Acid SCHEMBL30258420 | 0.99 | TSHR (0.40) | TSHRGLAPARP1PTGDR2NOTUM | |
| Hydrochloric Acid SCHEMBL23930745 | 0.87 | KEAP1 (0.38) | TSHRPARP1PTGDR2KEAP1S1PR5 | |
| Hydrochloric Acid SCHEMBL23930741 | 0.87 | KEAP1 (0.38) | TSHRPARP1PTGDR2KEAP1S1PR5 | |
| Hydrochloric Acid SCHEMBL23930754 | 0.83 | DRD2 (0.38) | TSHRKEAP1MEN1CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL23930750 | 0.83 | DRD2 (0.38) | TSHRKEAP1MEN1CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL30256269 | 0.83 | DRD2 (0.38) | TSHRKEAP1MEN1CYP3A4KMT2A | |
| SCHEMBL23930760 | 0.82 | PARP1 (0.45) | TSHRPARP1PTGDR2NOTUMALDH1A1 | |
| SCHEMBL30258583 | 0.78 | PARP1 (0.43) | PARP1PTGDR2ALDH1A1KEAP1 | |
| SCHEMBL30256409 | 0.78 | PARP1 (0.43) | PARP1PTGDR2ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159511-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | C4X DISCOVERY LIMITED (GB) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159511-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | NFE2L2, KEAP1, NQO1 | TSHR 3995/4885GLA 3410/4885PARP1 950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.