Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | REV1 | Q9UBZ9 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403555 | 0.78 | CA1 (0.56) | ALDH1A1GAAMAPTGFERDRD4 | |
| SCHEMBL4395782 | 0.78 | MAPT (0.60) | ALDH1A1GAAMAPTCYP1A2CYP3A4 | |
| SCHEMBL14980789 | 0.77 | GFER (0.57) | ALDH1A1KDM4EGAAHSP90AA1HSP90AB1 | |
| SCHEMBL6698451 | 0.76 | MAPT (0.59) | ALDH1A1KDM4EGAARAD52MAPT | |
| SCHEMBL10963122 | 0.76 | ME2 (0.58) | ALDH1A1KDM4EGAAMAPTPOLB | |
| SCHEMBL27615959 | 0.76 | KMT2A (0.56) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2661540 | 0.76 | ADRA2C (0.54) | ALDH1A1KDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL4400390 | 0.75 | SMN1; SMN2 (0.66) | ALDH1A1KDM4EMAPTCYP1A2CYP3A4 | |
| SCHEMBL6698448 | 0.75 | ALDH1A1 (0.61) | ALDH1A1KDM4EMAPTCYP1A2CYP3A4 | |
| SCHEMBL4179918 | 0.75 | GAA (0.60) | ALDH1A1GAAREV1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |