Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.35 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.35 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.35 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12340648 | 0.90 | SCN9A (0.35) | LMNASMN1; SMN2HTTALDH1A1SCN9A | |
| SCHEMBL12340659 | 0.89 | AURKA (0.39) | LMNASMN1; SMN2AURKAAURKBHTT | |
| SCHEMBL12340649 | 0.86 | TLR8 (0.38) | AURKAAURKBHTTNTRK1PLAAT3 | |
| SCHEMBL12340530 | 0.86 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2AURKAAURKBHTT | |
| SCHEMBL2551499 | 0.85 | PLAAT3 (0.49) | LMNASCN9APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL12788064 | 0.84 | LMNA (0.41) | LMNASMN1; SMN2AURKAAURKBHTT | |
| SCHEMBL2558496 | 0.83 | NPC1 (0.39) | AURKAAURKBHTTNTRK1PLAAT3 | |
| SCHEMBL2180038 | 0.82 | AURKA (0.39) | LMNASMN1; SMN2AURKAAURKBHTT | |
| SCHEMBL12340667 | 0.82 | LMNA (0.39) | LMNASMN1; SMN2HTTALDH1A1SCN9A | |
| SCHEMBL2554977 | 0.82 | FFAR1 (0.40) | LMNASMN1; SMN2HTTALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2557927-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-20 | — | — | EP | claimed |
| EP-2557926-A1 | FUNGICIDAL MIXTURES II COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-20 | — | — | EP | claimed |
| US-20130040813-A1 | Fungicidal mixtures II comprising quinazolines | BASF SE (DE) | 2013-02-14 | — | — | US | claimed |
| US-20130035229-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-07 | — | — | US | claimed |
| WO-2011128837-A1 | FUNGICIDAL MIXTURES II COMPRISING QUINAZOLINES | BASF SE (DE) | 2011-10-20 | — | — | WO | claimed |
| WO-2011128843-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2011-10-20 | — | — | WO | claimed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130040813-A1 | Fungicidal mixtures II comprising quinazolines | BASF SE (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20130035229-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | BASF SE (DE) | 2013-02-07 | — | — | US | disclosed |
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-8268843-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268843-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2012-09-18 | — | — | US | disclosed |
| WO-2010025451-A2 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | US | disclosed |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | LMNA 4092/4885SMN1; SMN2 2689/4885AURKA 2175/4885 |
| US-20130035229-A1 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES | CYP1A2, CYP3A7, CYP51A1 | LMNA 3857/4885SMN1; SMN2 3702/4885AURKA 1072/4885 |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | LMNA 4092/4885SMN1; SMN2 2689/4885AURKA 2175/4885 |
| US-20130040813-A1 | Fungicidal mixtures II comprising quinazolines | CYP1A2, CYP3A7, CYP51A1 | LMNA 4312/4885SMN1; SMN2 3731/4885AURKA 1171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.