Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 12/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.35 |
| ▸ | ESRRG | P62508 | 2/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25565756 | 0.84 | KDM4E (0.47) | MAPTKDM4EGAA | |
| SCHEMBL25565747 | 0.71 | CHRM4 (0.43) | MAPTKDM4EGAA | |
| SCHEMBL347279 | 0.71 | MAPT (0.63) | MAPTKDM4EGAA | |
| SCHEMBL30427138 | 0.68 | MAPT (0.56) | MAPTKDM4EGAA | |
| SCHEMBL2210399 | 0.68 | MAPT (0.56) | MAPTKDM4EGAA | |
| SCHEMBL3783390 | 0.66 | MAPT (0.53) | MAPTKDM4EGAA | |
| SCHEMBL10127415 | 0.65 | FGFR3 (0.50) | MAPTKDM4ECDK4CDK2 | |
| SCHEMBL30309444 | 0.65 | BRAF (0.46) | MAPTKDM4EGAACDK4CDK2 | |
| SCHEMBL22164002 | 0.65 | BRAF (0.46) | MAPTKDM4EGAACDK4CDK2 | |
| SCHEMBL3790341 | 0.65 | MAPT (0.51) | MAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023094310-A1 | PYRAZOLOTRIAZINE DERIVATIVES USEFUL AS CDK9 INHIBITORS | ORIGENIS GMBH (DE) | 2023-06-01 | — | — | WO | disclosed |