SCHEMBL25567374

SCHEMBL25567374

C(=C(/Cc1ccc(-c2ccc(N(c3ccccc3)c3ccccc3)cc2)cc1)c1ccc(-c2ccc(N(c3ccccc3)c3ccc(-c4ccc(N(c5ccccc5)c5ccccc5)cc4)cc3)cc2)cc1)\c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.38
ABCC4 O15439 1/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
TSHR P16473 1/20 0.38
HTT P42858 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
SRD5A2 P31213 1/20 0.36
MTNR1A P48039 2/20 0.36
MTNR1B P49286 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TP53 P04637 1/20 0.36
LTB4R2 Q9NPC1 1/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
NR1H4 Q96RI1 1/20 0.35
PTGS2 P35354 1/20 0.35
CYP19A1 P11511 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23341316 0.89 PTGS1 (0.33) PTGS1ABCC4LMNAGAATSHR
SCHEMBL14228497 0.88 ALDH1A1 (0.46) PTGS1ABCC4LMNAGAATSHR
SCHEMBL12194691 0.87 BCHE (0.39) LMNAGAACYP3A4CYP2C9SRD5A2
SCHEMBL14570728 0.86 CYP3A4 (0.40) PTGS1LMNAGAAHTTCYP3A4
SCHEMBL23620701 0.86 AKR1C4 (0.38)
SCHEMBL19393548 0.86 LTB4R2 (0.39) PTGS1ABCC4LMNAGAATSHR
SCHEMBL22060937 0.85 LTB4R2 (0.36) PTGS1ABCC4LMNAGAATSHR
SCHEMBL22892448 0.81 PTGES (0.38) PTGS1NR1H4PTGS2
SCHEMBL13515155 0.81 ESR1 (0.31) LMNAGAAHTTCYP3A4CYP2C9
SCHEMBL22355625 0.81 RXRA (0.32) PTGS1ABCC4LMNAGAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4186898-A1 COMPOSITION FOR ORGANIC ELECTRONIC COMPOUNDS Merck Patent GmbH (DE) 2023-05-31 EP disclosed