SCHEMBL2556747

SCHEMBL2556747

CC(C)(C)OC(=O)N1Cc2cc(C3(Cl)CCC(c4cccnc4)CC3)ccc2-n2cnnc2C1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
KDM1A O60341 1/20 0.37
GPR119 Q8TDV5 3/20 0.37
OXTR P30559 2/20 0.36
HSD11B1 P28845 2/20 0.35
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
AVPR1A P37288 1/20 0.35
CYP11B2 P19099 1/20 0.35
NAMPT P43490 7/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2550063 0.91 NAMPT (0.40) KDM1AGPR119OXTRDDB1CRBN
SCHEMBL2559351 0.89 GPR119 (0.35) KDM1AGPR119OXTRDDB1CRBN
SCHEMBL2579657 0.88 OXTR (0.36) GPR119OXTRDDB1CRBNAVPR1A
SCHEMBL2577034 0.87 POLB (0.38) GPR119OXTRDDB1CRBNAVPR1A
SCHEMBL2565485 0.87 FNTA (0.37) GPR119OXTRDDB1CRBNAVPR1A
SCHEMBL2581930 0.87 OXTR (0.34) GPR119OXTRDDB1CRBNAVPR1A
SCHEMBL2577744 0.87 OXTR (0.35) GPR119OXTRDDB1CRBNAVPR1A
SCHEMBL2565904 0.86 AVPR2 (0.37) GPR119OXTRHSD11B1DDB1CRBN
SCHEMBL2552066 0.86 GPR119 (0.38) GPR119OXTRDDB1CRBNAVPR1A
SCHEMBL2579958 0.86 OXTR (0.34) GPR119OXTRDDB1CRBNAVPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2560975-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2013-02-27 EP claimed
WO-2011131596-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2011-10-27 WO claimed
EP-2560975-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2013-02-27 EP disclosed
WO-2011131596-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2011-10-27 WO disclosed