Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.38 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2550063 | 0.89 | NAMPT (0.40) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2549514 | 0.86 | MGLL (0.35) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2556747 | 0.86 | HDAC1 (0.38) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2473876 | 0.85 | GPR119 (0.47) | GPR119ALKOXTRDDB1CRBN | |
| SCHEMBL2579657 | 0.85 | OXTR (0.36) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2574746 | 0.84 | OXTR (0.34) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2580300 | 0.84 | OXTR (0.36) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2575034 | 0.83 | GPR119 (0.33) | GPR119NOTCH1OXTRNAMPT | |
| SCHEMBL2565904 | 0.83 | AVPR2 (0.37) | GPR119OXTRDDB1CRBNAVPR1A | |
| SCHEMBL2580027 | 0.83 | DDB1 (0.36) | GPR119OXTRDDB1CRBNAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552919-A1 | ARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. Hoffmann-La Roche AG (CH) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120877-A1 | ARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-06 | — | — | WO | disclosed |