Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25568169 | 1.00 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL129763 | 0.88 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL2621297 | 0.88 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL2621386 | 0.88 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL19139368 | 0.88 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL30865762 | 0.88 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL25568175 | 0.87 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1MAPTHPGDCCR5 | |
| SCHEMBL18976649 | 0.87 | HTR2C (0.51) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL1058888 | 0.86 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1HTR2CMAPTHPGD | |
| SCHEMBL12093095 | 0.86 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1MAPTHPGDCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | TCOF1, SLC10A2, PAM | SIGMAR1 1994/4885ALDH1A1 4179/4885HTR2C 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.