SCHEMBL25568847

SCHEMBL25568847

O=C(O)c1ccc(C(=O)OC2CC(c3ccccc3)CC2c2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 1/20 0.46
CHRM2 P08172 2/20 0.40
CHRM4 P08173 2/20 0.40
CHRM1 P11229 2/20 0.40
CHRM3 P20309 2/20 0.40
GRIN2B Q13224 2/20 0.40
HSD11B1 P28845 1/20 0.39
EPHX2 P34913 1/20 0.39
CHRNA7 P36544 2/20 0.38
HSP90AB1 P08238 1/20 0.38
KDM1A O60341 3/20 0.37
HTR3E A5X5Y0 1/20 0.37
HTR3B O95264 1/20 0.37
HTR3A P46098 1/20 0.37
HTR3D Q70Z44 1/20 0.37
HTR3C Q8WXA8 1/20 0.37
BCHE P06276 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20503243 0.83 CHRM2 (0.50) SLC18A3CHRM2CHRM4CHRM1CHRM3
SCHEMBL20897888 0.83 CHRM2 (0.50) SLC18A3CHRM2CHRM4CHRM1CHRM3
SCHEMBL1623587 0.73 CHRNA7 (0.61) SLC18A3CHRNA7HTR3EHTR3BHTR3A
SCHEMBL1623586 0.73 CHRNA7 (0.61) SLC18A3CHRNA7HTR3EHTR3BHTR3A
SCHEMBL20897834 0.72 TSHR (0.52) KDM1A
SCHEMBL20897633 0.72 TSHR (0.52) KDM1A
SCHEMBL8440091 0.72 TSHR (0.52) KDM1A
SCHEMBL14256226 0.71 REN (0.45) SLC18A3CHRM2CHRM4CHRM1CHRM3
SCHEMBL8097764 0.71 HDAC4 (0.46) KDM1A
SCHEMBL31718053 0.70 TSHR (0.57) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230167447-A1 Compositions for FNIP1/FNIP2 Gene Modulation and Methods Thereof GENETIC INTELLIGENCE INC (US) 2023-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167447-A1 Compositions for FNIP1/FNIP2 Gene Modulation and Methods Thereof FNIP1, FN1, TNNC1 SLC18A3 3295/4885CHRM2 4273/4885CHRM4 4575/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.