Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | MAOA | P21397 | 7/20 | 0.43 |
| ▸ | KDM1A | O60341 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11458171 | 0.86 | HDAC4 (0.44) | HDAC4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL14714313 | 0.85 | ALDH1A1 (0.50) | HDAC4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL3170686 | 0.85 | SMN1; SMN2 (0.50) | HDAC4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL14714314 | 0.85 | ALDH1A1 (0.50) | HDAC4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL20897888 | 0.83 | CHRM2 (0.50) | LMNA | |
| SCHEMBL20503243 | 0.83 | CHRM2 (0.50) | LMNA | |
| SCHEMBL9032168 | 0.83 | SLC9A1 (0.44) | SLC6A2HTR2CSLC6A3SLC9A1 | |
| SCHEMBL21826219 | 0.82 | FABP5 (0.51) | HDAC4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL25369792 | 0.79 | FABP5 (0.64) | HPGDSLC6A2FABP7FABP3FABP5 | |
| SCHEMBL21825849 | 0.79 | FABP5 (0.64) | HPGDSLC6A2FABP7FABP3FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795547-B1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AG (DE) | 2000-05-10 | — | — | EP | disclosed |
| EP-0795547-A1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-17 | — | — | EP | disclosed |