Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453826 | 0.86 | GPR119 (0.51) | KDM4EMAPTPKMGPR119THRB | |
| SCHEMBL4248138 | 0.85 | KDM4E (0.60) | TGFBR1KDM4EMAPTPKMGPR119 | |
| SCHEMBL23329642 | 0.85 | ALDH1A1 (0.59) | TGFBR1KDM4EPKMGPR119STS | |
| SCHEMBL7787129 | 0.84 | STS (0.48) | TGFBR1KDM4EMAPTPKMGPR119 | |
| SCHEMBL4773741 | 0.83 | MAPT (0.54) | TGFBR1KDM4EMAPTPKMGPR119 | |
| SCHEMBL796552 | 0.82 | KDM4E (0.57) | TGFBR1KDM4EPKMGPR119STS | |
| SCHEMBL22585197 | 0.82 | PTPN2 (0.47) | KDM4EMAPTPKMGPR119MMP13 | |
| SCHEMBL16112715 | 0.82 | TGFBR1 (0.54) | TGFBR1KDM4EMAPTPKMGPR119 | |
| SCHEMBL29716377 | 0.81 | GPR119 (0.63) | TGFBR1KDM4EMAPTPKMGPR119 | |
| SCHEMBL20015404 | 0.81 | MAOB (0.54) | TGFBR1KDM4EMAPTPKMGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3247707-B1 | 4-METHYLSULFONYL-SUBSTITUTED PIPERIDINE UREA COMPOUNDS USEFUL FOR THE TREATMENT OF CARDIAC DISORDERS SUCH AS DILATED CARDIOMYOPATHY (DCM) | MYOKARDIA INC (US) | 2023-05-31 | — | — | EP | disclosed |