Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 6/20 | 0.34 |
| ▸ | CDK4 | P11802 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2737272 | 0.83 | KDM4E (0.54) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL23181411 | 0.80 | RAB9A (0.54) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL20971704 | 0.80 | MAPT (0.54) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL11951646 | 0.78 | HPGD (0.42) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL12695026 | 0.78 | HPGD (0.51) | KDM4EMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11951619 | 0.74 | HSD17B10 (0.57) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL11951633 | 0.74 | CDK7 (0.46) | KDM4ERAB9AMAPTNPC1MEN1 | |
| SCHEMBL11951623 | 0.73 | CRHR1 (0.39) | KDM4EL3MBTL1MAPK1TP53CDK7 | |
| SCHEMBL25590740 | 0.72 | HSD17B10 (0.43) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL26973993 | 0.70 | CDK2 (0.33) | MAPK1CDK7CDK4CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4186895-A1 | COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF | TYK Medicines Inc. (CN) | 2023-05-31 | — | — | EP | disclosed |