SCHEMBL2559151

SCHEMBL2559151

CC(=O)c1ccc(-c2cnc(O)c(C(=O)O)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 2/20 0.49
MAPT P10636 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
SGK1 O00141 1/20 0.47
MAP4K4 O95819 7/20 0.46
PDGFRB P09619 1/20 0.45
PDGFRA P16234 1/20 0.45
MKNK1 Q9BUB5 1/20 0.44
MKNK2 Q9HBH9 1/20 0.44
IKBKE Q14164 1/20 0.43
TBK1 Q9UHD2 1/20 0.43
XDH P47989 1/20 0.43
MCL1 Q07820 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2562823 0.84 MAP4K4 (0.57) MAP4K4PDGFRBPDGFRAMKNK2IKBKE
SCHEMBL2558781 0.83 MAP4K4 (0.55) MAPTSMN1; SMN2SGK1MAP4K4MKNK1
SCHEMBL11817492 0.82 ACMSD (0.55) SGK1MAP4K4MCL1
SCHEMBL2560846 0.81 PDGFRB (0.48) HSD17B1MAPTSMN1; SMN2SGK1MAP4K4
SCHEMBL11012950 0.80 MCL1 (0.49) MAP4K4PDGFRBPDGFRAIKBKETBK1
SCHEMBL2555138 0.78 ALDH1A1 (0.46) MAP4K4PDGFRBPDGFRAIKBKETBK1
SCHEMBL3975183 0.77 MAP4K4 (0.58) MAPTMAP4K4RXRARXRB
SCHEMBL1169167 0.75 SMN1; SMN2 (0.74) HSD17B1MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL15960261 0.75 SMN1; SMN2 (0.74) HSD17B1MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL2560018 0.75 HSD17B1 (0.46) HSD17B1MAPTSMN1; SMN2SGK1MAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed