Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28098386 | 0.89 | GAA (0.41) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL27645900 | 0.84 | CYP2C9 (0.37) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL28251874 | 0.83 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL27589109 | 0.79 | ACHE (0.32) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL27768210 | 0.79 | MAPT (0.35) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL26750231 | 0.77 | MAPT (0.49) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL21016721 | 0.77 | ACHE (0.42) | SMN1; SMN2ALDH1A1ACHEMAPK1KDM4E | |
| SCHEMBL837536 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| SCHEMBL17660228 | 0.77 | ACHE (0.47) | CHRNB2CHRNA4CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9773688 | 0.77 | BLM (0.32) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167110-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | SCHRÖDINGER, INC. | 2023-06-01 | — | — | US | disclosed |
| CN-108699103-A | AMINE DERIVATIVES OF LUPANES WITH HIV MATURATION INHIBITORY ACTIVITY | 葛兰素史克知识产权第二有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-108368071-A | Compounds having HIV maturation inhibitory activity | 葛兰素史克知识产权第二有限公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-108349963-A | sodium channel blockers | 株式会社大熊制药 | 2018-07-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167110-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | JAK2, JAK3, STAT5B | CHRNB2 4830/4885CHRNA4 4848/4885CHRM1 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.