SCHEMBL2559615

SCHEMBL2559615

OB(O)c1cc(COc2ccccc2F)ccc1F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 4/20 0.56
ENPP2 Q13822 1/20 0.54
LIPE Q05469 1/20 0.51
LMNA P02545 2/20 0.44
HTT P42858 1/20 0.44
NPC1 O15118 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
CASP3 P42574 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
PTGER1 P34995 1/20 0.42
HTR6 P50406 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
DAO P14920 1/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
FFAR1 O14842 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2560924 0.88 RXRA (0.54) MRGPRX4ENPP2LIPELMNAHTT
SCHEMBL2561786 0.87 ENPP2 (0.57) MRGPRX4ENPP2LIPELMNAHTT
SCHEMBL18587224 0.82 ENPP2 (0.65) MRGPRX4ENPP2LIPELMNAHTT
SCHEMBL2563377 0.80 MAOB (0.55) NPC1CASP3RAB9ASENP7MAOA
SCHEMBL29957976 0.78 TSHR (0.48) MRGPRX4ENPP2LIPEPTGER1DAO
SCHEMBL2562828 0.78 MRGPRX4 (0.58) MRGPRX4MAOAMAOB
SCHEMBL2555799 0.76 ALDH1A1 (0.46) MRGPRX4ENPP2LIPELMNAHTT
SCHEMBL15331400 0.76 MAOB (0.54) MRGPRX4NPC1RAB9AMAOAMAOB
SCHEMBL2556050 0.76 MAOB (0.54) ENPP2NPC1CASP3RAB9ASENP7
SCHEMBL27521279 0.76 MRGPRX4 (0.63) MRGPRX4LMNAKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed