Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25673301 | 0.87 | ALDH1A1 (0.53) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL30533920 | 0.86 | ALDH1A1 (0.52) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL25220131 | 0.86 | ALDH1A1 (0.52) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL25268541 | 0.86 | ALDH1A1 (0.52) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL25598188 | 0.84 | ALDH1A1 (0.66) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL25269747 | 0.83 | PKM (0.48) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL25269748 | 0.83 | PKM (0.48) | ALDH1A1PKMLMNAKMT2AMEN1 | |
| SCHEMBL25599182 | 0.81 | LMNA (0.45) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL25599061 | 0.80 | NPC1 (0.40) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL25680779 | 0.80 | NPC1 (0.40) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |