Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL3 | P15374 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.34 |
| ▸ | CDK2 | P24941 | 9/20 | 0.34 |
| ▸ | CDK7 | P50613 | 9/20 | 0.34 |
| ▸ | CCNH | P51946 | 9/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.34 |
| ▸ | CCNK | O75909 | 3/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599817 | 0.89 | UCHL3 (0.37) | UCHL3CSF1RCCNA2CDK2CDK7 | |
| SCHEMBL25599631 | 0.89 | CDK7 (0.38) | UCHL3CSF1RCCNA2CDK2CDK7 | |
| SCHEMBL25682533 | 0.89 | CCNA2 (0.39) | UCHL3CSF1RCCNA2CDK2CDK7 | |
| SCHEMBL25599216 | 0.89 | CCNA2 (0.39) | UCHL3CSF1RCCNA2CDK2CDK7 | |
| SCHEMBL25599992 | 0.89 | UCHL3 (0.39) | UCHL3MAP3K7MAPK1MAP2K1FGFR4 | |
| SCHEMBL25599672 | 0.89 | CCNA2 (0.38) | UCHL3MAP3K7MAPK1MAP2K1CSF1R | |
| SCHEMBL25599717 | 0.89 | BRPF1 (0.39) | UCHL3CSF1RCTSCEGFR | |
| SCHEMBL25681855 | 0.89 | BRPF1 (0.39) | UCHL3CSF1RCTSCEGFR | |
| SCHEMBL25599623 | 0.88 | FGFR4 (0.36) | UCHL3CSF1RCCNA2CDK2CDK7 | |
| SCHEMBL25599260 | 0.87 | UCHL3 (0.35) | UCHL3CSF1RCCNA2CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |