Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CDK7 | P50613 | 3/20 | 0.38 |
| ▸ | CCNH | P51946 | 3/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.37 |
| ▸ | CCNK | O75909 | 4/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.37 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599631 | 0.89 | CDK7 (0.38) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25599817 | 0.89 | UCHL3 (0.37) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25682533 | 0.89 | CCNA2 (0.39) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25599216 | 0.89 | CCNA2 (0.39) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25599189 | 0.89 | UCHL3 (0.36) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25681855 | 0.89 | BRPF1 (0.39) | UCHL3EGFRCSF1R | |
| SCHEMBL25599717 | 0.89 | BRPF1 (0.39) | UCHL3EGFRCSF1R | |
| SCHEMBL25599623 | 0.88 | FGFR4 (0.36) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25599705 | 0.87 | UCHL3 (0.35) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL25599260 | 0.87 | UCHL3 (0.35) | CCNA2CDK2CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |