Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599685 | 0.90 | KCNH2 (0.37) | KCNH2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL25599242 | 0.90 | ALDH1A1 (0.40) | KCNH2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL25599724 | 0.89 | MAPT (0.45) | MAPTPKMMAPK1ALDH1A1MEN1 | |
| SCHEMBL25599801 | 0.86 | MAPT (0.42) | KCNH2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL25599269 | 0.85 | ALDH1A1 (0.35) | KCNH2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL25599642 | 0.84 | KCNH2 (0.37) | KCNH2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL25258893 | 0.82 | KCNH2 (0.40) | KCNH2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL25258895 | 0.82 | KCNH2 (0.40) | KCNH2MAPTPKMMAPK1ALDH1A1 | |
| SCHEMBL25599841 | 0.81 | KCNH2 (0.36) | KCNH2 | |
| SCHEMBL25220340 | 0.81 | KCNH2 (0.42) | KCNH2MAPTPKMMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |