Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599264 | 0.84 | KCNH2 (0.44) | KCNH2HSD11B1ALDH1A1PKMMEN1 | |
| SCHEMBL25599685 | 0.83 | KCNH2 (0.37) | KCNH2HSD11B1ALDH1A1PKMMEN1 | |
| SCHEMBL25599242 | 0.83 | ALDH1A1 (0.40) | KCNH2HSD11B1ALDH1A1PKMMEN1 | |
| SCHEMBL25681759 | 0.83 | DPP4 (0.36) | KCNH2DPP4CHRM3PDE4APDE4B | |
| SCHEMBL25599724 | 0.83 | MAPT (0.45) | ALDH1A1PKMMEN1KMT2ALMNA | |
| SCHEMBL25599801 | 0.80 | MAPT (0.42) | KCNH2DPP4ALDH1A1MEN1KMT2A | |
| SCHEMBL25599269 | 0.79 | ALDH1A1 (0.35) | KCNH2HSD11B1ALDH1A1PKMMEN1 | |
| SCHEMBL25599637 | 0.76 | UCHL3 (0.38) | DPP4 | |
| SCHEMBL25216705 | 0.75 | MET (0.33) | CYP2D6MAPT | |
| SCHEMBL30464393 | 0.75 | MET (0.33) | CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |