Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599264 | 0.90 | KCNH2 (0.44) | KCNH2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL25599242 | 0.89 | ALDH1A1 (0.40) | KCNH2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL25599724 | 0.88 | MAPT (0.45) | ALDH1A1MEN1KMT2AMAPTPKM | |
| SCHEMBL25599801 | 0.85 | MAPT (0.42) | KCNH2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25599269 | 0.84 | ALDH1A1 (0.35) | KCNH2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL25599642 | 0.83 | KCNH2 (0.37) | KCNH2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL25599182 | 0.76 | LMNA (0.45) | KCNH2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL17373793 | 0.73 | MAPT (0.43) | ALDH1A1MEN1KMT2AMAPTPKM | |
| SCHEMBL25279915 | 0.73 | CHRM4 (0.34) | PGK1MEN1KMT2AMAPTPKM | |
| SCHEMBL25285585 | 0.73 | CHRM4 (0.34) | PGK1MEN1KMT2AMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |