Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599264 | 0.89 | KCNH2 (0.44) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL25599242 | 0.88 | ALDH1A1 (0.40) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL25599685 | 0.88 | KCNH2 (0.37) | MAPTALDH1A1LMNAPKMMAPK1 | |
| SCHEMBL25599801 | 0.84 | MAPT (0.42) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL25599269 | 0.83 | ALDH1A1 (0.35) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL25599642 | 0.83 | KCNH2 (0.37) | MAPTALDH1A1CYP2D6LMNAPKM | |
| SCHEMBL25681867 | 0.81 | CHRM3 (0.38) | MAPTALDH1A1LMNAPKMHTT | |
| SCHEMBL17373793 | 0.79 | MAPT (0.43) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL16898921 | 0.77 | MAPT (0.41) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL25263303 | 0.76 | SERPINE1 (0.36) | MAPTALDH1A1CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |