Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25600419 | 0.87 | HSP90B1 (0.32) | HSP90B1TRAP1 | |
| SCHEMBL25600310 | 0.85 | MEN1 (0.37) | MAPTTAS1R3TAS1R1TAS1R2CYP19A1 | |
| SCHEMBL25215919 | 0.84 | F2 (0.38) | MAPTCYP19A1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL30970492 | 0.77 | AKR1C3 (0.34) | MAPTTAS1R3TAS1R1TAS1R2CYP19A1 | |
| SCHEMBL30970495 | 0.77 | F2 (0.35) | MAPTTAS1R3TAS1R1TAS1R2CYP19A1 | |
| SCHEMBL25670623 | 0.74 | THRA (0.42) | — | |
| SCHEMBL25600245 | 0.73 | POLB (0.38) | MAPTCYP19A1ALDH1A1KMT2AAKR1C3 | |
| SCHEMBL25212540 | 0.72 | F2 (0.36) | KMT2AGAAF2 | |
| SCHEMBL25210256 | 0.70 | TRAP1 (0.36) | HSP90B1TRAP1 | |
| SCHEMBL30377318 | 0.70 | TRAP1 (0.36) | HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023094834-A1 | ISOINDOLINES AS PMS2 INHIBITORS | Neophore Limited (GB) | 2023-06-01 | — | — | WO | disclosed |