SCHEMBL2560355

SCHEMBL2560355

O=Cc1cccc(C#CCO)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.52
UNG P13051 1/20 0.42
ALDH1A1 P00352 3/20 0.41
MELK Q14680 1/20 0.38
SRC P12931 1/20 0.38
TRIM24 O15164 1/20 0.37
TRIM33 Q9UPN9 1/20 0.37
CHRM2 P08172 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
MAOA P21397 4/20 0.36
MAOB P27338 4/20 0.36
MMP2 P08253 1/20 0.36
MMP12 P39900 1/20 0.36
CYP2A6 P11509 1/20 0.35
MAPK14 Q16539 1/20 0.35
EGFR P00533 1/20 0.34
KDM4E B2RXH2 2/20 0.34
PTGS2 P35354 1/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29622517 1.00 FFAR1 (0.52) FFAR1UNGALDH1A1MELKSRC
SCHEMBL3899508 0.86 FFAR1 (0.50) FFAR1UNGALDH1A1SRCTRIM24
SCHEMBL30688451 0.86 FFAR1 (0.50) FFAR1UNGALDH1A1SRCTRIM24
SCHEMBL10633500 0.82 FFAR1 (0.58) FFAR1UNGALDH1A1SRCTRIM24
SCHEMBL5633251 0.80 ALDH1A1 (0.47) FFAR1ALDH1A1MELKMMP2MMP12
SCHEMBL9559955 0.78 FFAR1 (0.52) FFAR1UNGALDH1A1MAOAMAOB
SCHEMBL2560937 0.77 MMP2 (0.47) FFAR1ALDH1A1MELKMMP2MMP12
SCHEMBL3735218 0.77 FFAR1 (0.62) FFAR1UNGALDH1A1TRIM24TRIM33
SCHEMBL29622470 0.77 FFAR1 (0.62) FFAR1UNGALDH1A1TRIM24TRIM33
SCHEMBL493774 0.77 FFAR1 (0.45) FFAR1ALDH1A1MMP2MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114437350-B Polyimide resin and preparation method and application thereof 波米科技有限公司 2022-09-16 CN claimed
CN-114437350-A Polyimide resin and preparation method and application thereof 波米科技有限公司 2022-05-06 CN claimed
CN-114315686-A Alkynyl-containing diamine, preparation method thereof and application thereof in preparation of photosensitive resin composition 波米科技有限公司 2022-04-12 CN claimed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
CN-114437350-B Polyimide resin and preparation method and application thereof 波米科技有限公司 2022-09-16 CN disclosed
CN-114315686-B Alkynyl-containing diamine, preparation method thereof and application thereof in preparation of photosensitive resin composition 波米科技有限公司 2022-09-06 CN disclosed
CN-114437350-A Polyimide resin and preparation method and application thereof 波米科技有限公司 2022-05-06 CN disclosed
CN-114315686-A Alkynyl-containing diamine, preparation method thereof and application thereof in preparation of photosensitive resin composition 波米科技有限公司 2022-04-12 CN disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed
EP-1102739-B1 GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS KAROBIO AB (SE) 2003-04-23 EP disclosed
US-6492424-B1 Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders KARO BIO AB (SE) 2002-12-10 US disclosed
EP-1102739-A1 GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS KARO BIO AB (SE) 2001-05-30 EP disclosed
WO-2000007972-A1 GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS KARO BIO AB (SE) 2000-02-17 WO disclosed