Sugi Predict

Sugi Predict / Compounds / SCHEMBL2562385

SCHEMBL2562385

SCHEMBL2562385

CC(C)(CNc1ncc(-c2cccc(C(N)=O)c2)cn1)c1ccc(F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CLK1 P49759 1/20 0.45
▸ FLT1 P17948 2/20 0.43
▸ CCNT1 O60563 1/20 0.43
▸ CCND1 P24385 1/20 0.43
▸ CCNC P24863 1/20 0.43
▸ CDK8 P49336 1/20 0.43
▸ CDK7 P50613 1/20 0.43
▸ CDK9 P50750 1/20 0.43
▸ CCNH P51946 1/20 0.43
▸ MNAT1 P51948 1/20 0.43
▸ CDK6 Q00534 1/20 0.43
▸ VEGFA P15692 1/20 0.43
▸ EGLN1 Q9GZT9 1/20 0.43
▸ HPGDS O60760 1/20 0.43
▸ SYK P43405 2/20 0.43
▸ CHEK2 O96017 2/20 0.43
▸ CDC7 O00311 1/20 0.43
▸ PLK4 O00444 1/20 0.43
▸ CHEK1 O14757 1/20 0.43
▸ AURKA O14965 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29724975 1.00 CLK1 (0.45) CLK1FLT1CCNT1CCND1CCNC
SCHEMBL15009106 0.89 CLK1 (0.43) CLK1HPGDSKDRMAPK8MAPK9
SCHEMBL15009129 0.88 CCR6 (0.47) CLK1FLT1CCNT1CCND1CCNC
SCHEMBL12288595 0.87 ULK1 (0.41) VNN1ULK1
SCHEMBL29724758 0.87 ULK1 (0.41) VNN1ULK1
SCHEMBL12288597 0.87 VNN1 (0.44) VNN1ULK1
SCHEMBL29724739 0.83 FLT1 (0.42) CLK1FLT1CCNT1CCND1CCNC
SCHEMBL12288403 0.83 FLT1 (0.42) CLK1FLT1CCNT1CCND1CCNC
SCHEMBL2565358 0.82 CLK1 (0.41) CLK1FLT1CCNT1CCND1CCNC
SCHEMBL13718081 0.82 NPC1 (0.47) CLK1SYKCDK2KDRPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230026651-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS CYTOKINETICS, INC. 2023-01-26 — — US disclosed
US-20230026651-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS CYTOKINETICS, INC. 2023-01-26 — — US disclosed
US-11369565-B2 Amino-pyrimidine skeletal muscle modulators CYTOKINETICS, INC. (US) 2022-06-28 — — US disclosed
US-11369565-B2 Amino-pyrimidine skeletal muscle modulators CYTOKINETICS, INC. (US) 2022-06-28 — — US disclosed
US-20210045997-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS CYTOKINETICS, INC. 2021-02-18 — — US disclosed
US-20210045997-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS CYTOKINETICS, INC. 2021-02-18 — — US disclosed
CN-112047926-A Certain amino-pyrimidines, compositions thereof and methods of use thereof 赛特凯恩蒂克公司 2020-12-08 — — CN disclosed
US-10765624-B2 Amino-pyrimidine skeletal muscle modulators CYTOKINETICS, INC. (US) 2020-09-08 — — US disclosed
US-10765624-B2 Amino-pyrimidine skeletal muscle modulators CYTOKINETICS, INC. (US) 2020-09-08 — — US disclosed
EP-3698795-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE Cytokinetics, Inc. (US) 2020-08-26 — — EP disclosed
US-20140206709-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. 2014-07-24 — — US disclosed
US-20140206709-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. 2014-07-24 — — US disclosed
US-20140206709-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. 2014-07-24 — — US disclosed
US-20130123289-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. (US) 2013-05-16 — — US disclosed
US-20130123289-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. (US) 2013-05-16 — — US disclosed
US-20130123289-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. (US) 2013-05-16 — — US disclosed
CN-103025331-A Certain amino-pyrimidines, compositions thereof and methods of use thereof CYTOKINETICS INC 2013-04-03 — — CN disclosed
EP-2560653-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE Cytokinetics, Inc. (US) 2013-02-27 — — EP disclosed
WO-2011133888-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. (US) 2011-10-27 — — WO disclosed
WO-2011133888-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE CYTOKINETICS, INC. (US) 2011-10-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11369565-B2 Amino-pyrimidine skeletal muscle modulators MUSK, PYGM, TNNC1 CLK1 3606/4885FLT1 2262/4885CCNT1 671/4885
US-10765624-B2 Amino-pyrimidine skeletal muscle modulators MUSK, PYGM, TNNC1 CLK1 3149/4885FLT1 2484/4885CCNT1 605/4885
US-20230026651-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS MUSK, PYGM, TNNC1 CLK1 3149/4885FLT1 2484/4885CCNT1 605/4885
US-20210045997-A1 AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS MUSK, PYGM, TNNC1 CLK1 3606/4885FLT1 2262/4885CCNT1 671/4885
US-20140206709-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE HPRT1, TYMP, TYMS CLK1 3453/4885FLT1 1295/4885CCNT1 168/4885
US-20130123289-A1 CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE HPRT1, TYMP, TYMS CLK1 3453/4885FLT1 1295/4885CCNT1 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.