Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128024 | 0.71 | NOS1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL1995649 | 0.71 | SLC6A3 (0.31) | — | |
| SCHEMBL18071029 | 0.69 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL31078390 | 0.69 | ALDH1A1 (0.34) | FFAR2ALDH1A1 | |
| SCHEMBL12206091 | 0.69 | — | — | |
| SCHEMBL16432464 | 0.69 | — | — | |
| SCHEMBL18179469 | 0.68 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL31206756 | 0.67 | CA12 (0.46) | MEN1KMT2AALDH1A1 | |
| SCHEMBL25165495 | 0.67 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL2470516 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023108108-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023108103-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-15 | — | — | WO | disclosed |