Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561432 | 0.88 | HSD17B10 (0.46) | KDM4ESLC1A5ALDH1A1CYP3A4MAPT | |
| SCHEMBL2562353 | 0.85 | KDM4E (0.52) | KDM4EPOLBSMN1; SMN2SLC1A5MTNR1B | |
| SCHEMBL8002569 | 0.84 | MTNR1B (0.54) | KDM4EPOLBSLC1A5MTNR1BALDH1A1 | |
| SCHEMBL9151951 | 0.83 | MTNR1B (0.53) | KDM4EPOLBSLC1A5MTNR1BALDH1A1 | |
| SCHEMBL9159002 | 0.82 | HSD17B10 (0.49) | KDM4EALDH1A1CYP3A4MAPTL3MBTL1 | |
| SCHEMBL9152712 | 0.82 | MAOB (0.45) | KDM4ESMN1; SMN2SLC1A5MTNR1BALDH1A1 | |
| SCHEMBL2561207 | 0.81 | TBXA2R (0.58) | KDM4EPOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9150938 | 0.76 | KDM4E (0.48) | KDM4EPOLBSLC1A5MTNR1BALDH1A1 | |
| SCHEMBL30104106 | 0.74 | HSD17B10 (0.73) | KDM4EMTNR1BALDH1A1HSD17B10MEN1 | |
| SCHEMBL5316111 | 0.74 | MAPT (0.66) | KDM4EPOLBSMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |