Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560656 | 0.88 | KDM4E (0.49) | HSD17B10ALDH1A1KDM4EHPGDSLC6A4 | |
| SCHEMBL9159002 | 0.85 | HSD17B10 (0.49) | HSD17B10ALDH1A1KDM4EMAPK1L3MBTL1 | |
| SCHEMBL2561757 | 0.83 | SLC6A4 (0.47) | HSD17B10ALDH1A1KDM4EHPGDHTR2A | |
| SCHEMBL7254516 | 0.80 | SLC6A4 (0.56) | ALDH1A1HPGDHTR2ASLC6A4SLC1A5 | |
| SCHEMBL2555691 | 0.79 | TBXA2R (0.55) | ALDH1A1MAPK1MAPTGAAMEN1 | |
| SCHEMBL30104106 | 0.77 | HSD17B10 (0.73) | HSD17B10ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL4981706 | 0.77 | HSD17B10 (0.73) | HSD17B10ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL2557947 | 0.77 | SLC6A4 (0.49) | HSD17B10ALDH1A1KDM4EHPGDHTR2A | |
| SCHEMBL8144382 | 0.77 | ALDH1A1 (0.47) | HSD17B10ALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL1624350 | 0.76 | GAA (0.61) | ALDH1A1KDM4EHPGDMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |