SCHEMBL2560842

SCHEMBL2560842

Nc1ccn(C=CC=O)c(=O)n1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PDE3A Q14432 3/20 0.33
PDE4D Q08499 1/20 0.33
SLC29A1 Q99808 1/20 0.33
LMNA P02545 3/20 0.33
THRB P10828 1/20 0.33
MTOR P42345 1/20 0.33
MDM2 Q00987 1/20 0.33
NCOA1 Q15788 1/20 0.33
NCOA3 Q9Y6Q9 1/20 0.33
CACNA1F O60840 2/20 0.31
ALB P02768 2/20 0.31
MAPT P10636 2/20 0.31
CACNA1D Q01668 2/20 0.31
CACNA1S Q13698 2/20 0.31
CACNA1C Q13936 2/20 0.31
FGFR1 P11362 2/20 0.31
SLC22A6 Q4U2R8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1179743 0.81 PDE3A (0.36) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL21925892 0.80 PDE3A (0.34) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL19681300 0.80 PDE3A (0.34) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL23772976 0.76 PDE3A (0.35) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL19857181 0.76 PDE3A (0.38) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL2465397 0.76 PDE3A (0.35) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL20385875 0.71 LMNA (0.33) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL21734464 0.70 PDE3A (0.34) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL440453 0.67 PDE3A (0.35) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL22016090 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed
US-20050004225-A1 Oxidoreductase inhibitors and methods of screening and using thereof CITY OF HOPE 2005-01-06 US disclosed
US-6294380-B1 Liver cell clones for use in extracorporeal liver-assist device JMS CO., LTD. (JP) 2001-09-25 US disclosed
EP-1063289-A1 Liver cell clones for artifical liver and extracorporeal liver assist device JMS Co., Ltd. (JP) 2000-12-27 EP disclosed