Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.61 |
| ▸ | ABL1 | P00519 | 9/20 | 0.61 |
| ▸ | EGFR | P00533 | 9/20 | 0.61 |
| ▸ | ABL2 | P42684 | 8/20 | 0.61 |
| ▸ | RET | P07949 | 4/20 | 0.60 |
| ▸ | LCK | P06239 | 3/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | MST1R | Q04912 | 2/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640804 | 0.94 | SRC (0.59) | SRCABL1EGFRABL2RET | |
| SCHEMBL16769984 | 0.87 | RET (0.58) | SRCABL1EGFRABL2RET | |
| SCHEMBL29780883 | 0.87 | RET (0.58) | SRCABL1EGFRABL2RET | |
| Hydrochloric Acid SCHEMBL28341793 | 0.86 | METTL3 (0.57) | SRCABL1EGFRABL2RET | |
| Hydrochloric Acid SCHEMBL29720924 | 0.86 | METTL3 (0.57) | SRCABL1EGFRABL2RET | |
| SCHEMBL17085734 | 0.86 | ADK (0.51) | SRCABL1EGFRABL2RET | |
| SCHEMBL870154 | 0.84 | METTL3 (0.58) | SRCABL1EGFRABL2RET | |
| SCHEMBL869590 | 0.82 | ADK (0.53) | SRCABL1EGFRABL2RET | |
| SCHEMBL16769992 | 0.82 | ABL1 (0.63) | SRCABL1EGFRABL2LCK | |
| SCHEMBL400626 | 0.82 | SRC (0.61) | SRCABL1EGFRABL2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102228-A1 | HETEROCYCLIC COMPOPUNDS AS GCN2 AND PERK KINASE INHIBITORS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-08 | — | — | WO | disclosed |