Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.61 |
| ▸ | ABL1 | P00519 | 10/20 | 0.61 |
| ▸ | EGFR | P00533 | 9/20 | 0.61 |
| ▸ | ABL2 | P42684 | 9/20 | 0.61 |
| ▸ | RET | P07949 | 5/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | MST1R | Q04912 | 2/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24072104 | 0.94 | RIPK2 (0.61) | SRCABL1EGFRABL2RET | |
| SCHEMBL14644244 | 0.87 | RIPK2 (0.52) | SRCABL1EGFRABL2RET | |
| SCHEMBL10261381 | 0.87 | FGR (0.57) | SRCABL1EGFRABL2RET | |
| SCHEMBL24651203 | 0.85 | ABL1 (0.49) | SRCABL1EGFRABL2RET | |
| SCHEMBL14643787 | 0.84 | ADK (0.52) | SRCABL1EGFRABL2RET | |
| SCHEMBL19563041 | 0.84 | ADK (0.55) | SRCABL1EGFRABL2RET | |
| SCHEMBL14643106 | 0.84 | ADK (0.52) | SRCABL1EGFRABL2RET | |
| SCHEMBL10261916 | 0.84 | ADK (0.55) | SRCABL1EGFRABL2RET | |
| SCHEMBL24251908 | 0.82 | ADK (0.48) | SRCABL1EGFRABL2RET | |
| SCHEMBL19264034 | 0.82 | ADK (0.53) | SRCABL1EGFRABL2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021242505-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-02 | — | — | WO | disclosed |
| WO-2021155004-A1 | STRAD-BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-05 | — | — | WO | disclosed |
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |