Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628099 | 0.80 | ALDH1A1 (0.49) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL623999 | 0.77 | MAPT (0.55) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL624634 | 0.77 | MAPT (0.52) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL627055 | 0.76 | MAPT (0.48) | MAPTTHRBLMNASMN1; SMN2KDM4E | |
| SCHEMBL2561682 | 0.73 | RAB9A (0.67) | MAPTTHRBLMNATP53ALDH1A1 | |
| SCHEMBL628264 | 0.73 | BTK (0.51) | MAPTTHRBPOLB | |
| SCHEMBL30277649 | 0.72 | ALDH1A1 (0.55) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL22061402 | 0.72 | ALDH1A1 (0.55) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL628000 | 0.71 | MAPT (0.42) | MAPTTHRBPOLBLMNAGAA | |
| SCHEMBL2565666 | 0.71 | MAPT (0.61) | MAPTTHRBTP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |