Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15566600 | 0.82 | HTR2C (0.43) | MGLLNOTUMADAM10MMP2HDAC4 | |
| SCHEMBL23380258 | 0.81 | NOTUM (0.52) | MGLLNOTUMADAM10MMP2ROCK2 | |
| SCHEMBL26816768 | 0.81 | NOTUM (0.43) | MGLLNOTUMADAM10MMP2ROCK2 | |
| SCHEMBL25996817 | 0.80 | SOS1 (0.36) | MGLLNOTUMADAM10MMP2ROCK2 | |
| SCHEMBL6388862 | 0.76 | ESR2 (0.43) | MGLLNOTUMADAM10MMP2HDAC4 | |
| SCHEMBL7634263 | 0.75 | HDAC4 (0.47) | ADAM10MMP2HDAC4HDAC2HDAC8 | |
| SCHEMBL5667630 | 0.74 | KMO (0.49) | ADAM10MMP2ROCK2HDAC4HDAC2 | |
| SCHEMBL26816772 | 0.74 | MGLL (0.42) | MGLLNOTUMADAM10HDAC4HDAC2 | |
| SCHEMBL5670741 | 0.73 | ESR2 (0.43) | MGLLNOTUMADAM10MMP2HDAC4 | |
| SCHEMBL16961065 | 0.72 | HTR2C (0.41) | NOTUMROCK2PRKG1HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814331-B1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO INC (US) | 2023-06-14 | — | — | EP | disclosed |