Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 6/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23380258 | 0.88 | NOTUM (0.52) | NOTUMMGLLADAM10MMP2ROCK2 | |
| SCHEMBL15566600 | 0.85 | HTR2C (0.43) | NOTUMMGLLADAM10MMP2ERBB2 | |
| SCHEMBL25619706 | 0.81 | MGLL (0.38) | NOTUMMGLLADAM10MMP2ROCK2 | |
| SCHEMBL5670914 | 0.79 | QDPR (0.57) | NOTUMADAM10MMP2ERBB2SOS1 | |
| SCHEMBL6388862 | 0.79 | ESR2 (0.43) | NOTUMMGLLADAM10MMP2ERBB2 | |
| SCHEMBL7634263 | 0.79 | HDAC4 (0.47) | ADAM10MMP2ERBB2KDM4EMDM4 | |
| SCHEMBL27754753 | 0.78 | KMO (0.42) | NOTUMROCK2PRKG1KDM4EALDH1A1 | |
| SCHEMBL25996817 | 0.77 | SOS1 (0.36) | NOTUMMGLLADAM10MMP2ROCK2 | |
| SCHEMBL5667630 | 0.77 | KMO (0.49) | ADAM10MMP2ROCK2ERBB2KDM4E | |
| SCHEMBL23381188 | 0.77 | NOTUM (0.50) | NOTUMMGLLADAM10MMP2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | NR1H2, NR1H3, NR1H4 | NOTUM 2359/4885MGLL 356/4885ADAM10 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.