Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253139 | 0.80 | ALDH1A1 (0.51) | NR3C1NR3C2TAAR1NPC1RAB9A | |
| SCHEMBL11922803 | 0.71 | CHRM2 (0.47) | TAAR1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL11728106 | 0.71 | LIPG (0.34) | KDM4E | |
| SCHEMBL6562301 | 0.70 | TAAR1 (0.59) | TAAR1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL5136256 | 0.70 | CHRM2 (0.43) | NR3C1NR3C2TAAR1ALDH1A1KDM4E | |
| SCHEMBL18844905 | 0.69 | TLR2 (0.49) | — | |
| SCHEMBL20794423 | 0.69 | TLR2 (0.49) | — | |
| SCHEMBL7530042 | 0.69 | NR3C1 (0.43) | NR3C1NR3C2TAAR1ALDH1A1KDM4E | |
| SCHEMBL6549903 | 0.69 | TAAR1 (0.57) | TAAR1ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL9699152 | 0.69 | TAAR1 (0.57) | TAAR1ALDH1A1KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |