SCHEMBL256218

SCHEMBL256218

COC(=O)C(C(=O)c1ncc(F)cc1F)c1ccccc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 3/20 0.39
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
ALDH1A1 P00352 2/20 0.37
LMNA P02545 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HDAC3 O15379 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
MAPK1 P28482 2/20 0.34
CTSA P10619 2/20 0.34
RECQL P46063 1/20 0.34
ROCK2 O75116 2/20 0.34
ROCK1 Q13464 2/20 0.34
P2RY1 P47900 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17535497 0.88 ALDH1A1 (0.36) HDAC4CES2CES1ALDH1A1LMNA
SCHEMBL15187740 0.88 CES2 (0.38) HDAC4CES2CES1KMT2AHDAC3
SCHEMBL3578523 0.82 MAPK1 (0.39) ALDH1A1LMNAMEN1KMT2AMAPK1
SCHEMBL30059683 0.78 ALDH1A1 (0.56) CES2CES1ALDH1A1LMNAMEN1
SCHEMBL1274762 0.78 ALDH1A1 (0.56) CES2CES1ALDH1A1LMNAMEN1
SCHEMBL21862847 0.72 MAPK1 (0.51) ALDH1A1MEN1KMT2AMAPK1RECQL
SCHEMBL8210564 0.72 TDP1 (0.46) CES2CES1ALDH1A1LMNAMEN1
SCHEMBL12780298 0.70 DPP4 (0.40) CES2CES1
SCHEMBL29738141 0.70 NPSR1 (0.43) ALDH1A1LMNAMAPK1
SCHEMBL644695 0.70 NPSR1 (0.43) ALDH1A1LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230257398-A1 PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF CHIA TAL TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2023-08-17 US disclosed
US-20230257398-A1 PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF CHIA TAL TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2023-08-17 US disclosed
EP-2802587-B1 SUBSTITUTED, ANNELLATED IMIDAZOLES AND PYRAZOLES AND THEIR USE BAYER IP GMBH (DE) 2017-09-06 EP disclosed
EP-2802587-B1 SUBSTITUTED, ANNELLATED IMIDAZOLES AND PYRAZOLES AND THEIR USE BAYER IP GMBH (DE) 2017-09-06 EP disclosed
US-9309239-B2 Substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-04-12 US disclosed
US-9309239-B2 Substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-04-12 US disclosed
US-9309239-B2 Substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-04-12 US disclosed
EP-2611802-B1 BICYCLIC AZA-HETEROCYCLES AND THEIR USE BAYER IP GMBH (DE) 2016-02-24 EP disclosed
EP-2611802-B1 BICYCLIC AZA-HETEROCYCLES AND THEIR USE BAYER IP GMBH (DE) 2016-02-24 EP disclosed
US-9096592-B2 Bicyclic aza heterocycles, and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-08-04 US disclosed
US-20140148433-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-05-29 US disclosed
US-20130267548-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-10-10 US disclosed
US-20130267548-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-10-10 US disclosed
US-20130267548-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-10-10 US disclosed
US-20130210824-A1 Substituted fused imidazoles and pyrazoles and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-15 US disclosed
WO-2013104598-A2 SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-07-18 WO disclosed
WO-2013104598-A2 SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-07-18 WO disclosed
WO-2012059548-A1 BENZYL-SUBSTITUTED CARBAMATES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-10 WO disclosed
WO-2012059549-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-10 WO disclosed
WO-2012028647-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257398-A1 PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF TYMP, TYMS, DPYD HDAC4 3726/4885CES2 2345/4885CES1 2183/4885
US-20130210824-A1 Substituted fused imidazoles and pyrazoles and use thereof CYP4F3, CYP11B2, CYP4F2 HDAC4 500/4885CES2 1908/4885CES1 491/4885
US-20140148433-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF AADAC, PAICS, TPMT HDAC4 126/4885CES2 563/4885CES1 744/4885
US-20130267548-A1 SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF PNPO, CYP4F3, PDXK HDAC4 1183/4885CES2 1146/4885CES1 308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.