Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558333 | 1.00 | MAOA (0.51) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL9914144 | 1.00 | MAOA (0.51) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL6823748 | 1.00 | MAOA (0.51) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL7620931 | 1.00 | MAOA (0.51) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL16471843 | 0.89 | L3MBTL1 (0.47) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL16478537 | 0.85 | RAB9A (0.45) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL16478538 | 0.84 | PDE2A (0.47) | MAOANR4A1USP2ALDH1A1MAPT | |
| SCHEMBL16459872 | 0.83 | MAOA (0.49) | MAOANR4A1USP2ALDH1A1MEN1 | |
| SCHEMBL16459874 | 0.83 | MAOA (0.49) | MAOANR4A1USP2ALDH1A1MEN1 | |
| SCHEMBL20526848 | 0.82 | MAOA (0.55) | MAOANR4A1USP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205657-A1 | OSMIUM (II) ARENE IMINO ANTI-CANCER COMPLEXES | University of Warwick (GB) | 2017-08-16 | — | — | EP | disclosed |
| US-9598448-B2 | Osmium (II) arene imino anti-cancer complexes | UNIVERSITY OF WARWICK (GB) | 2017-03-21 | — | — | US | disclosed |
| EP-2560980-B1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIV WARWICK (GB) | 2017-01-25 | — | — | EP | disclosed |
| US-20160272663-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIVERSITY OF WARWICK (GB) | 2016-09-22 | — | — | US | disclosed |
| US-9296772-B2 | Osmium (II) arene azo anti-cancer complexes | THE UNIVERSITY OF WARWICK (GB) | 2016-03-29 | — | — | US | disclosed |
| EP-2560980-A2 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | University of Warwick (GB) | 2013-02-27 | — | — | EP | disclosed |
| US-20130040925-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIVERSITY OF WARWICK (GB) | 2013-02-14 | — | — | US | disclosed |
| WO-2011131925-A2 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIVERSITY OF WARWICK (GB) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272663-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | TP53, SLC30A5, IDH1 | MAOA 4342/4885NR4A1 1364/4885USP2 4186/4885 |
| US-20130040925-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | TP53, SLC30A5, IDH1 | MAOA 4342/4885NR4A1 1364/4885USP2 4186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.